Transitioning from Basic PK/PD to Systems Pharmacology

Presented by William Jusko, PhD

Building upon many classical foundations of pharmacology, a diverse array of mechanistic pharmacokinetic-pharmacodynamic (PK/PD) models have emerged based on mechanisms of drug action and primary rate-limiting or turnover processes in physiology. This array of basic models can be extended to handle various complexities including tolerance and can readily be employed as building blocks in assembling enhanced PK/PD or small systems models.  Our corticosteroid PK/PD models demonstrate these concepts as well as elements of horizontal and vertical integration of molecular to whole-body processes. The potential advantages and challenges in moving PK/PD towards systems models will be described.


Date: Monday, July 27, 2015
Location: Lambertville Station
 11 Bridge Street
 Lambertville, NJ 08530

- Reception/Networking/Chatting (with cash bar)5:30-6:30 pm
-Presentation 6:30-7:30
Dinner 7:30-9:30 pm

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Costs: The registration fee covers location booking and dinner. 

  • $45 for ISoP members and $55 for non-members .

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